10-Undecenoic acid, zinc (2+) salt
Zinc undecylenate
CAS: 557-08-4
Molecular Formula: C22H38O4Zn
10-Undecenoic acid, zinc (2+) salt - Names and Identifiers
| Name | Zinc undecylenate |
| Synonyms | Tineafax NSC 402438 Mycoseptin UNII-388VZ25DUR zinc undecanoate Zinc undecylenate Zinc 10-undecenoate ZINCUNDECYLENATE,USP zinc undec-10-enoate Undecylenic acid zinc Zinc diundec-10-enoate 10-Undecenoic Acid Zinc Zinc undecylenate [USAN] 10-Undecenoic acid, zinc salt 10-Undecylenic acid zinc salt Bis(10-undecenoic acid)zinc salt 10-Undecenoic acid, zinc (2+) salt |
| CAS | 557-08-4 |
| EINECS | 209-155-0 |
| InChI | InChI=1/C11H20O2.Zn/c1-2-3-4-5-6-7-8-9-10-11(12)13;/h2H,1,3-10H2,(H,12,13) |
10-Undecenoic acid, zinc (2+) salt - Physico-chemical Properties
| Molecular Formula | C22H38O4Zn |
| Molar Mass | 431.92 |
| Melting Point | 118-121 °C (lit.) |
| Solubility | Practically insoluble in water and in ethanol (96 per cent). |
| Vapor Density | 14.9 (vs air) |
| Appearance | White powder |
| Specific Gravity | 1.1 |
| Merck | 13,9916 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | 4: no reaction with water under neutral conditions |
| MDL | MFCD00067246 |
| Physical and Chemical Properties | White amorphous powder. Melting point 115-116 °c. Practically insoluble in water and alcohol. |
| Use | Antifungal, for the treatment of fungal infections of the skin |
10-Undecenoic acid, zinc (2+) salt - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| TSCA | No |
10-Undecenoic acid, zinc (2+) salt - Standard
Authoritative Data Verified Data
This product is zinc 10-11-enoate salt. The content of C22H3804zn should be 98.0% to 102.0%.
Last Update：2024-01-02 23:10:35
10-Undecenoic acid, zinc (2+) salt - Trait
Authoritative Data Verified Data
This product is a white amorphous powder.
This product is almost insoluble in water or ethanol.
melting point
The melting point of this product (General 0612) is 116~121°C.
Last Update：2022-01-01 11:30:21
10-Undecenoic acid, zinc (2+) salt - Differential diagnosis
Authoritative Data Verified Data
- take about 3g of this product, add 20ml of water and 25ml of dilute sulfuric acid, shake with diethyl ether for 2 times, 25ml each time, combine the ether extract, set the water bath to distill diethyl ether, 1ml of the residual liquid was taken, and the same reaction was shown according to the test of identification (1) under the item of 11 enoic acid.
- take about 0.lg of this product, add 10ml of water and lml of concentrated ammonia test solution to dissolve, add several drops of sodium sulfide test solution to generate white precipitate.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 18).
Last Update：2022-01-01 11:30:22
10-Undecenoic acid, zinc (2+) salt - Exam
Authoritative Data Verified Data
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
alkali and alkaline earth metal salts
take 1.5g of this product, add 50ml of water and 10ml of hydrochloric acid, boil, filter with wet filter paper while hot, and wash with hot water until the wash solution does not show acidic reaction; Combine filtrate and wash solution, put it in a 200ml measuring flask, add ammonia solution to make it alkaline, and add an appropriate amount of ammonium sulfide solution to make zinc precipitate completely. Dilute it with water until it is calibrated, shake it well, and filter it. Take 100ml of filtrate and add 0.5ml of sulfuric acid, the residue should not exceed 7.5mg after evaporation and ignition to constant weight.
Last Update：2022-01-01 11:30:22
10-Undecenoic acid, zinc (2+) salt - Content determination
Authoritative Data Verified Data
take about 0.5g of this product, weigh it accurately, add 10ml of lmol/L hydrochloric acid solution and 10ml of water to boil for 10 minutes, filter it while it is hot, and wash the filter residue with hot water, combine the filtrate and wash solution, cool, add 1 drop of 0.025% methyl red ethanol solution, add an appropriate amount of ammonia test solution to the solution of microscopic yellow, add water to make the total amount of about 35ml, then add ammonia-ammonium chloride buffer (pH10.0)10ml with a small amount of Chrome Black T indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration to the solution from purple to pure blue. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 21.60mg of C22H3804Zn.
Last Update：2022-01-01 11:30:23
10-Undecenoic acid, zinc (2+) salt - Category
Authoritative Data Verified Data
Disinfection antiseptic.
Last Update：2022-01-01 11:30:23
10-Undecenoic acid, zinc (2+) salt - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:30:23
10-Undecenoic acid, zinc (2+) salt - Compound zinc fenenate ointment
Authoritative Data Verified Data
This product contains zinc (C22H3804Zn) should be 18.5% ~ 21.5%, containing the total amount of 11 acid should be 19.8% ~ 23.8%.
prescription
zinc (Ⅱ)-(Ⅱ)-(Ⅱ)-(Ⅱ)
Undecanoic acid 50g
Appropriate amount of matrix
lOOOg
trait
This product is white to light yellow ointment.
identification
- take about 5g of this product, add 25ml of ethanol, heat, shake, cool, filter, add several drops of potassium permanganate test solution to the filtrate, and shake, the color of potassium permanganate will disappear.
- take the remaining filter residue, add chloroform 10ml, slightly warm to dissolve, let it cool, add dilute sulfuric acid 20ml, shake, and let it stand once layered, the acid solution of the upper layer shows the identification reaction of the zinc salt (General rule 0301).
- the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution in the chromatogram recorded under the determination of the total content of 11 enoic acid.
examination
should be in accordance with the relevant provisions under the item of soft cement (General 0109).
Content determination
- zinc (ii)-(ii)-(ii)-(ii)-(ii)-(ii) zinc-(ii)-(ii)-(ii)-(ii)-(ii)-(ii)-(ii) zinc-(ii)-(I)-(ii)-(ii)-(ii), after the oil layer was clarified, the mixture was heated to 20ml of water, stirred, allowed to stand, cooled, 1 drop of 0.025% methyl red ethanol solution was added, and appropriate amount of ammonia test solution was added until the solution was yellowish, 10ml of ammonia-ammonium chloride buffer solution (pH 10.0) and a small amount of Chrome Black T indicator were added, and the solution was titrated with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) until the solution changed from purple to pure blue. Each l of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) corresponds to 21.60mg of C22H3804Zn.
- the total amount of 11 enoic acid was measured by gas chromatography (General 0521).
- chromatographic conditions and system suitability test: dimethylpolysiloxane (or similar polarity) was used as the stationary liquid, and the column temperature was 210°C; The inlet temperature and detector temperature were both 250°C. The resolution between internal standard peak and the peak of 11 enoic acid should be greater than 5.0. The theoretical plate number is not less than 10000 based on the calculation of the 11 enoic acid peak.
- preparation of internal standard solution an appropriate amount of 11 alkane was taken and chloroform was added to prepare a solution containing about 3mg per 1 ml.
- determination of this product about 0.4g, precision weighing, set Erlenmeyer flask, add hydrochloric acid solution (l-50)25ml, water bath heating, shaking, until the oil layer is clear, cool, transfer to a separatory funnel and extract three times with chloroform (30ml, 20ml, 20ml). Combine the extracts, put them in a lOOml measuring flask, add 5ml of internal standard solution precisely, dilute them with chloroform to the scale, shake them well, use them as the sample solution, take lul precisely, and inject it into human gas chromatograph, record the chromatogram; Take about 80mg of the reference substance of 11 enoic acid, put it in a 100ml measuring flask, measure it with the same method, and calculate it by peak area according to internal standard method.
category
The same as zinc.
storage
sealed storage.
Last Update：2022-01-01 11:30:24
10-Undecenoic acid, zinc (2+) salt - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | zinc undecenoate is a natural or synthetic antifungal fatty acid, topical application, anti-fungal infection, eczema, ringworm, and other skin problems, zinc has a astringent effect. |
| Use | This product is an anti-mildew drug, and it is made into beriberyl ointment, which can be used for skin mycosis. Can also be used in cosmetics. Zinc 11 is also used as an intermediate in organic synthesis. Antifungal Agents for the treatment of fungal skin infections |
| production method | is derived from the reaction of refined 11 enoic acid with zinc oxide. Raw material consumption (kg/t) of 11 enoic acid 960 zinc oxide 20095% ethanol 2300 |
Last Update：2024-04-09 15:16:51
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View History
10-Undecenoic acid, zinc (2+) salt
12H-[1]苯并噻吩并[2,3-A]咔唑
2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride
(1S)-1-(2-ANTHRYL)BUT-3-ENYLAMINE
(S)-2-HYDROXY-4-METHYLVALERIC ACID
1-Pyrenebutanoic acid
Phosphonium, methyltriphenyl-, bromide
12H-[1]苯并噻吩并[2,3-A]咔唑
2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride
(1S)-1-(2-ANTHRYL)BUT-3-ENYLAMINE
(S)-2-HYDROXY-4-METHYLVALERIC ACID
1-Pyrenebutanoic acid
Phosphonium, methyltriphenyl-, bromide